For the past nine years, he has been engaged in a long term photographic research on the memories of the slave trade and slavery. This ambitious project, entitled "Cham", has had and will continue to have stages in Africa, the Caribbean and America.

His photographs have been exhibited in numerous museums, art centers and festivals, including MACAAL in Marrakesh, Afriques Capitales in Lille, the Musée des Confluences in Lyon, the Musée National Alinari de la Photographie in Florence, the Fondation Zinzou in Cotonou and the Tropenmuseum in Amsterdam.

He is present in many private and public collections, including the Lightwork collection in Syracuse (NY), the Alinari Archives in Florence, the Pinacoteca Civica in Monza, the Bibliothèque Nationale de France in Paris or the Tropenmuseum in Amsterdam.

From 2015 to 2019, Lo Calzo directed the "Kazal" project, a photographic masterclass with the photographers of Kolektif D2, around the memory of crime under the Duvalier dictatorship, the first project of its kind in Haiti. The project, produced by the Fokal Foundation, was published by André Frére.

Kehrer, Andrè Frère and Alinari Editions have published several books by Nicola Lo Calzo: Regla (2017), Obia (2015), Inside Niger (2012) as well as Morgante (2011). He is also a regular contributor to the international press, including "Le Monde" (daily and magazine), "The New Yorker", "The New York Times" and "Internazionale". In 2018, he was a recipient of the CNAP grant and nominated for the 2019-2020 Elysee Prize.

Nicola Lo Calzo is represented by the Dominique FIAT Gallery in Paris.